Qiankun Li

Lane detection is a crucial task in autonomous driving, as it helps ensure the safe operation of vehicles. However, existing datasets such as CULane and TuSimple contain relatively limited data under extreme weather conditions, including rain, snow, and fog. As a result, detection models trained on these datasets often become unreliable in such environments, which may lead to serious safety-critical failures on the road. To address this issue, we propose HG-Lane, a High-fidelity Generation framework for Lane Scenes under adverse weather and lighting conditions without requiring re-annotation. Based on this framework, we further construct a benchmark that includes adverse weather and lighting scenarios, containing 30,000 images. Experimental results demonstrate that our method consistently and significantly improves the performance of existing lane detection networks. For example, using the state-of-the-art CLRNet, the overall mF1 score on our benchmark increases by 20.87 percent. The F1@50 score for the overall, normal, snow, rain, fog, night, and dusk categories increases by 19.75 percent, 8.63 percent, 38.8 percent, 14.96 percent, 26.84 percent, 21.5 percent, and 12.04 percent, respectively. The code and dataset are available at: https://github.com/zdc233/HG-Lane.

Missed and delayed diagnosis remains a major challenge in rare disease care. At the initial clinical encounters, physicians assess rare disease risk using only limited information under high uncertainty. When high-risk patients are not recognised at this stage, targeted diagnostic testing is often not initiated, resulting in missed diagnosis. Existing primary care triage processes are structurally insufficient to reliably identify patients with rare diseases at initial clinical presentation and universal screening is needed to reduce diagnostic delay. Here we present RareAlert, an early screening system which predict patient-level rare disease risk from routinely available primary-visit information. RareAlert integrates reasoning generated by ten LLMs, calibrates and weights these signals using machine learning, and distils the aligned reasoning into a single locally deployable model. To develop and evaluate RareAlert, we curated RareBench, a real-world dataset of 158,666 cases covering 33 Orphanet disease categories and more than 7,000 rare conditions, including both rare and non-rare presentations. The results showed that rare disease identification can be reconceptualised as a universal uncertainty resolution process applied to the general patient population. On an independent test set, RareAlert, a Qwen3-4B based model trained with calibrated reasoning signals, achieved an AUC of 0.917, outperforming the best machine learning ensemble and all evaluated LLMs, including GPT-5, DeepSeek-R1, Claude-3.7-Sonnet, o3-mini, Gemini-2.5-Pro, and Qwen3-235B. These findings demonstrate the diversity in LLM medical reasoning and the effectiveness of aligning such reasoning in highly uncertain clinical tasks. By incorporating calibrated reasoning into a single model, RareAlert enables accurate, privacy-preserving, and scalable rare disease risk screening suitable for large-scale local deployment.